According to Darwin, people who know little about science are more confident about the limits of science than those who know a lot. For example, those who know little about science may be certain that science will never be able to solve mysteries such as why humans feel emotions and how life became existent.

A common problem in the modern world is the use of the internet for self-diagnosis. Patients read online articles on the possible conditions that they may be suffering from and gain incorrect knowledge. Some patients remain adamant that they are suffering from a certain illness when in reality, they may have a completely different condition.

On the contrary, a person who has extended knowledge about a subject may become certain that progress in that particular subject is not possible. In such a case, it is important for someone else, who is less knowledgable, to study that subject and ensure whether progress is possible or not. In 1934, Albert Einstein said that it is not possible to obtain nuclear energy. In 1954, the USSR managed to supply electricity using nuclear power.
Different opinions are always necessary for science as they can often provide weaknesses and flaws in researches.

There is some truth to the statement made by Darwin. However, it is not applicable to all situations and hence should not be generalised.